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WP1      Acute HCV cohorts in Egypt
To maintain a well-characterized cohort of patients with acute hepatitis C in Egypt and identify patients with and without spontaneous viral clearance.
WP2 Inflammatory and antibody signatures
To construct a signature of the inflammatory response for acute viral hepatitis using multi-analyte profiling  (MAP) and validate plasma biomarkers that are predictive for spontaneous viral clearance.
WP3 Analysis of cellular activation during spontaneous resolution of HCV
To define cellular signatures predictive of spontaneous clearance of acute HCV and provide mechanistic insight into the determinants of anti-viral immunity.
WP4 Genetic analysis of polymorphisms correlating with spontaneous resolution of HCV
To identify the genetic polymorphisms pre-disposing HCV clearance vs. chronicity in an Egyptian population.
WP5 Training opportunities in Clinical epidemiology & Biomarker discovery
To provide training in clinical epidemiology and biomarker discovery.
WP6 Project Management
To establish a Consortium that collaborates efficiently and works toward the stated objectives, while protecting intellectual property and fulfilling EC requirements.
WP7 Collaboration with Hepacute and STDF projects
To ensure coherence and collaboration between Hepacute and STDF funded projects.


SPHINX-HepaCute joint workshop EASL conference, London April 9th 2014


Sphinx researchers to translate biomarker discoveries onto point of care technologies in new FP7 project, PoC-HCV

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This project is
funded by the
European Union